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Joseph Novo

1998 Research

Abstract: Cognitive Symptoms of Depression as Predictors of Unconscious

Mentor: Phillip Watkins, Psychology

This study investigated whether specific symptoms of depression have a predictive relationship with implicit mood-congruent memory (MCM) bias. The authors correlated data from three previous MCM studies that used conceptually driven implicit memory tests. The implicit MCM bias scores were compared to individual symptoms and attitudes from undergraduate participants assessed by two instruments designed to assess the severity of depression (BDI and SADS-C). We found that conceptually driven implicit memory bias tends to correlate more with cognitive symptoms of depression. The pattern of results supports the hypothesis that basic cognitive biases are at the root of negative cognitive symptoms in depression.

1997 Research

Abstract: Cryopreservation of the Drosophila melanogaster Orer-P2 strain

Mentor: Dr. Charles Herr, Biology

Drosophila melanogaster is a species of fruit fly that is widely studied in biology. The use of Drosophila as a research tool, particularly in Genetics, is popular because of the high degree of sophistication involved in the genetic analysis of this organism. Over time, thousands of new Drosophila strains have emerged. In more recent times, researchers have obtained a wealth of knowledge of many fundamental biological problems based on studies of this organism. Because this organism has such a short life span and is always mutating into new and different strains, continued research of this organism is expensive and tedious. Dan Lindsey (Ashburner) estimates that at least 15,000 different stocks of Drosophila were maintained in Drosophila stock centers such as the European Stock Center (about 1600 stocks) at one time in 1985. This process is expensive, time consuming, and risky. For many years, scientists working with mice could maintain their stocks by freezing mouse embryos. In recent years work on freezing Drosophila embryos has achieved a 25% success rate (Ashburner) (Mazur and Cole). The idea behind freezing Drosophila stocks would offer a cost effective and convenient method of indefinitely shelving thousands of strains of this organism rather than changing live cultures as often as every 7-10 days in order to maintain each strain. Through there has been some success in freezing Drosophila embryos, the success rate is too low to be able to confidently replace current live stocks with frozen stocks.

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